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KMID : 0921620140440010112
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Journal of Bacteriology and Virology
2014 Volume.44 No. 1 p.112 ~ p.114
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cGAS-cGAMP Signaling and Antiviral Defense
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Manzoor Zahid
Koh Young-Sang
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Abstract
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Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a cytosolic DNA sensor that plays an important role in innate immunity. Transfection of DNA or DNA virus infection results in the induction of type I interferon production in fibroblasts, macrophages, and dendritic cells which is dependent on cGAS. Recently, cGas-/- mice have been reported to be more vulnerable to fatal infection with herpes simplex virus 1 (HSV1) as compared to wild-type mice.
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KEYWORD
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Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS), Type I interferons, DNA sensor, Antiviral defense
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